APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16
Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...
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Background: Various studies proposed virus infection is to be a possible cause of human breast cancer. However, the data argue the association between virus and cancer are inconsistent. This study was conducted to detect whether HPV-DNA is present in tissue samples of breast cancer in Isfahan province. Materials and Methods: Paraffin embedded formalin fixed specimens were prepared from 40 brea...
متن کاملHuman papillomavirus genotype 16 pseudovirus production and purification in HEK-293FT cells
Introduction: Human papillomavirus (HPV) is the main causative agent of cervical cancer worldwide leading to a big health problem, especially in the developing countries. Among 14 common high-risk genotypes, HPV16 accounts for more than 50% of all cervical cancers. The current prophylactic vaccines against HPV infection are based on L1 protein. Due to some drawbacks in the current vaccines such...
متن کاملThe 3' region of Human Papillomavirus type 16 early mRNAs decrease expression
BACKGROUND High risk human papillomavirus (HR-HPV) infects mucosal surfaces and HR-HPV infection is required for development of cervical cancer. Accordingly, enforced expression of the early HR-HPV proteins can induce immortalisation of human cells. In most cervical cancers and cervical cancer cell lines the HR-HPV double stranded DNA genome has been integrated into the host cell genome. METH...
متن کاملRoles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression
The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family of cytidine deaminases plays an important role in the innate immune response to viral infections by editing viral genomes. However, the cytidine deaminase activity of APOBEC3 enzymes also induces somatic mutations in host genomes, which may drive cancer progression. Recent studies of human papillom...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2015
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2014.12.103